The A-MSystems Model 2400 patch clamp amplifier is the ideal solution for researchers who want to invest in a multi-functional amplifier. This brilliantly priced amplifier is the perfect solution for whole cell patch clamp, single channel recordings, current clamp and extracellular recordings.
Each headstage has a switchable dual resistor setting, where two of the following values are built in: 10 MΩ, 50 MΩ, 100 MΩ, 1 GΩ, 5 GΩ, and 10 GΩ. The default headstage shipped with each amplifier is the 100 MΩ/10 GΩ version, but alternative headstages can be specified or added to the setup at a later stage. Once the headstage is connected, the amplifier automatically detects the resistor settings to adjust internal gain settings, without any additional scaling factor inputs required of the user.
The 2400 Patch Clamp Amplifier offers a set of preprogrammed command potentials. For more complex potentials, an external command input is typically used. In addition to the command potentials, the system features independent offset control, voltage/current tracking circuitry and holding potential selection settings.
The digital meter on the 2400 Amplifier front panel displays accurate values of:
The built-in series resistance compensation provides the researcher with the option of selecting either or both predictive and corrective compensation from zero to 100%. Fine and coarse controls for lag provide sensitive control to minimize oscillation produced by compensation close to 100%. Separate compensation controls exist for eliminating transients seen during current clamp experiments when the bridge balance is used.
The analogue BNC output connectors for telegraphing various signals offers you the option of additional monitoring channels, including noise, gain, filter, mode and error signals. These telegraphs allow the 2400 Amplifier’s front panel settings to be automatically recorded by your system software.
For labs who require extra wide bandwidths, the raw bandwidth of the entire amplifier may be adjusted via a rear panel potentiometer. The system has a built-in 6-position 4-pole Low-Pass Bessel Filter for signal conditioning.
The A-MSystems patch clamp amplifier is a tried-and-tested solution (see references below) for a wide range of electrophysiology applications. The system includes a 3-year warranty period, and this flexibility and reliability is available for less than £3,000 per amplifier, including a headstage.
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Smith AJ, Sugita S, and Charlton MP. (2010) Cholesterol-dependent kinase activity regulates transmitter release from cerebellar synapses. J Neuroscience 30(17): 6116-6121
Del Negro CA et al. (2009) Asymmetric control of inspiratory and expiratory phases by excitability in the respiratory network of neonatal mice in vitro. J Physiology 587: 1217-1231
Olsen SR and Wilson RI. (2008) Lateral presynaptic inhibition mediates gain control in an olfactory circuit. Nature 452:956-960 Del Negro CA et al. (2009) Asymmetric control of inspiratory and expiratory phases by excitability in the respiratory network of neonatal mice in vitro. J Physiology 587: 1217-1231
Yao CA, Ingell R, and Carlson JR (2005) Chemosensory coding by neurons in the coeloconic sensilla of the Drosophila Antenna. J Neuroscience 25(37): 8359-8367 S