jULIEs – juxtaneuronal Ultra-Low Impedance Electrodes – are minimally invasive microwire-based pseudocapacitive sensors for extracellular neuronal recordings and stimulation. From Neurotrodics, they achieve high signal to noise ratios with no detectable functional damage to the micro-neural network and the blood-brain-barrier.
jULIEs have at their core, cylindrical composite microwires with OD 25µm±1µm and ID 2µm± 0.5µm with tips angle polished (<30° degrees) to seamlessly penetrate and advance in tissue with minimal tissue displacement and functional perturbation. Each microwire has a recording site surrounded by insulation located at the tip, modified with nanomaterials to enable superior electrical coupling to extracellular signals as well as increase charge storage capacity for stimulation purposes. Sites can be down to 50x smaller than those of conventional Si-probes electrodes i.e. sites can be 2µm to 7µm in diameter.
jULIEs have been validated in the mouse olfactory bulb, and were found to be very well-suited for recording large amplitude, well isolated single units and multi-units from electrogenic cells in the immediate vicinity of the sites i.e. a recording from a neuron 10µm away generates a measurable 1.6mV spike. This research can be viewed more closely on the brochure.
Depending on the brain region of interest, probes can have different channel counts and sensor layout arrangements. In a standard example, microwires are arranged in parallel rows and have 16, 32, 64 or 128 channels packed in a rectangular or circular fashion.
jULIEs are highly customisable: for example, sensor sites can be packed in rectangular, circular or cascaded fashion and custom inter-shank distances at starting at 10µm with up to a 1024 channels.
jULIEs are compatible with Intan-based amplifier electronics and are equipped with MOLC-FOLC, DIL, Mill-Max and Omnetics connector plugs for direct connection to the head-stages. Convertors can be provided in cases where other connectorization is required. Probes are compatible with Open-Ephys, Neuralynx, Plexon, White-Matter, LeafLabs, Spike Gadgets and other amplifications systems and their software.
Don’t plan your experiments around available probes! We want to encourage scientist to FOCUS on asking the most exciting biological, behavioural or pharmacological question, then COME UP with the ideal probe specification so we can build it and ship it.
If you already know what your ideal neural probe would look like, or you want to know what more jULIEs can do for your experiments, do get in touch with our friendly team and we’ll build you your perfect solution.