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Pryer Lens

A powerful tool for deep tissue imaging at sub-micron resolution

High-resolution imaging of deep tissue without being highly invasive is difficult to achieve. Therefore, a new imaging method that allows non- or minimally- invasive image acquisition in vivo and in real time with sub-cellular spatial resolution, and at sub-second sampling rates is needed.

MCI now offers a new promising imaging method that allows minimally- invasive image acquisition in vivo and in real time with sub-cellular spatial resolution – the MCI Pryer Endoscopic Objective (abbreviated as MCI Pryer). The MCI Pryer is a combined endoscopic objective and is compatible with any fluorescence microscopes, such as current 2P microscopes from Olympus and Nikon. This state-of-the-art objective allows for deep tissue access and visualization in anesthetized animals, awake animals with head fixation and even chronic recordings with our custom-built adaptor.

Pryer Lens

pryer lens1

Full Specification

  1. Probing tip: 5.67mm length and 2.1mm diameter
  2. Magnification: 70X; NA=0.8
  3. Resolution = 0.3micron (can resolve organelles such as dendritic spines, filopodia, etc)
  4. Working distance > 300micron; VOF > 200um
  5. Working band: 450nm-1030nm
  6. Image quality: Plan Fluoro Achromatic NIR
  7. Compatibility: All upright fluorescence microscopes including bright field microscopes, confocal, 2P and super resolution microscopes STEDimage 5

The advantages of using MCI Pryer in a nutshell

  1. Can be easily integrated into most (Olympus, Nikon, etc) current 2P microscopes, and giving excellent spatiotemporal resolution of <0.3μm
  2. Minimally invasive recordings from deep tissues such as brain regions (e.g. hippocampus) using anesthetized animals or awake animals that are head-fixed
  3. Provides access to any organ or tissue from the surface to deep structures
  4. Potential for longitudinal studies
  5. Real-time imaging 
  6. Record dynamic changes in vivo
  7. Can be used to study drug uptake
  8. Easily tailored to your application and adapt to your needs
  9. Has the potential to be used in a broad-range of applications, for instance: cancerology, molecular imaging, immunology, virology, botany, etc.

Add the Pryer Lens to your quote basket or get in touch with our friendly applications team to discuss your requirements in greater detail.

  • Brochure