A powerful tool for deep tissue imaging at sub-micron resolution
High-resolution imaging of deep tissue without being highly invasive is difficult to achieve. Therefore, a new imaging method that allows non- or minimally- invasive image acquisition in vivo and in real time with sub-cellular spatial resolution, and at sub-second sampling rates is needed.
MCI now offers a new promising imaging method that allows minimally- invasive image acquisition in vivo and in real time with sub-cellular spatial resolution – the MCI Pryer Endoscopic Objective (abbreviated as MCI Pryer). The MCI Pryer is a combined endoscopic objective and is compatible with any fluorescence microscopes, such as current 2P microscopes from Olympus and Nikon. This state-of-the-art objective allows for deep tissue access and visualization in anesthetized animals, awake animals with head fixation and even chronic recordings with our custom-built adaptor.
- Probing tip: 5.67mm length and 2.1mm diameter
- Magnification: 70X; NA=0.8
- Resolution = 0.3micron (can resolve organelles such as dendritic spines, filopodia, etc)
- Working distance > 300micron; VOF > 200um
- Working band: 450nm-1030nm
- Image quality: Plan Fluoro Achromatic NIR
- Compatibility: All upright fluorescence microscopes including bright field microscopes, confocal, 2P and super resolution microscopes STED
The advantages of using MCI Pryer in a nutshell
- Can be easily integrated into most (Olympus, Nikon, etc) current 2P microscopes, and giving excellent spatiotemporal resolution of <0.3μm
- Minimally invasive recordings from deep tissues such as brain regions (e.g. hippocampus) using anesthetized animals or awake animals that are head-fixed
- Provides access to any organ or tissue from the surface to deep structures
- Potential for longitudinal studies
- Real-time imaging
- Record dynamic changes in vivo
- Can be used to study drug uptake
- Easily tailored to your application and adapt to your needs
- Has the potential to be used in a broad-range of applications, for instance: cancerology, molecular imaging, immunology, virology, botany, etc.
Add the Pryer Lens to your quote basket or get in touch with our friendly applications team to discuss your requirements in greater detail.